Vector field techniques for the detection of neuronal dynamics in the presence of mercury

Авторы

  • Gradov, O.V. 1
  • 1 N. N. Semenov Federal Research Center for Chemical Physics of the Russian Academy of Sciences (FRC CP RAS), Kosygina str. 4, Moscow, 119991, Russia

DOI:

https://doi.org/10.31951/2658-3518-2022-A-3-1273

Ключевые слова:

mercury, ecotoxicology, axonal guiding, axonal pathfinding, motion estimation, vector fields

Аннотация

The role of mercury in the development of various neuropathologies is well known. The biogeochemical cycles of mercury indicate the possibility of its introduction into various organisms (including humans) through the corresponding trophic chains. However, as it turns out from the literature analysis, until recent years, there have been almost no works on the dynamic microscopic study (either in situ or in vivo) of the processes of connectome involution in aquatic organisms (including fishes, marine mammals, etc.) under the action of mercury. In this regard, we attempted to study the dynamics of morphogenesis and breakdown of the emerging connectome under the mercury exposure. A dynamic study of frames with the dynamics of the axonal path search was carried out in a series with an address-time code, on which it is possible to track the vector fields of displacements and reactiondiffusion processes in the cell culture immediately after the introduction of a drop of mercury or a mercury-containing liquid using capillary pipettes. This paper describes the observed effects and the possible mechanisms underlying them.

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Опубликован

31.07.2022

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